Wayne State University School of Medicine - Yearbook (Detroit, MI)

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-' v al J 4' ..4, v. 'P J - , 2 S wif f 1' I ,fp ,f t E415 vw. 3.2 150 -xy 5 First study of Robert Koch C1843-19109. l f

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'wsnillllllllil i fl 'l11'!!1!'.l..i:i,s it I lltllir 1 l ll 'lllgl WSE ll , ' gwglllrzl in .limlllliiti . l1LH..lE'1iIvwm1lll1 e I , llllllllll if ,l -. . filth: 1 W,,,,c - 'N , ll ll l E E uname sm 1 'll ll' f 1 Hull' Inu ,sf .k FX x5 ,ii .. THE ONTOGENY OF SOLUBLE LENS PROTEINS The soluble lens proteins were studied using biochemical electrophoretic and immunological techniques. The problem of lens differentiation was studied in several parts as follows: lj Qualitative and quantitative changes in crystallin composition during development. 25 Nuclear and cortical differences in protein composi- tion during development. 3D Embryonic proteins Cwith gamma crystallin mobilityl were identified by starch gel electrophoresis in lenses of several species. The gamma crystallins of the beef lens were eluted from starch gel and studied immunologically. 45 The characterization of protein composition in the lens epithelial cell. , 5D Changes in LDH activity during lens aging, and nu- clear and cortical differences. 65 LDI-I isozyme activity in the lens epithelial cell. Larry H. Bernstein Harry Maisel, M.D. 149

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ANTIBIOTIC SENSITIVITY PATTERN OF URINARY BACTERIA Infection ofthe urinary tract is one of the rnost difficult thera- peutic problems in medicine today. Over the past decade numer- ous antimicrobial agents have been used in the treatment only to sec the emergence of antibiotic-resistant strains. Antimicrobial drugs have also resulted in modification in the bacterial flora commonly encountered in urinary tract infections. Recently, authors have emphasized the lethal consequences of gram- negativc bacteremia, and McCabe has demonstrated that the urinary tract is the most common site of primary infection leading to bactcriemia. ln view of the importance of this problem and the numerous antibiotics in common therapeutic use, this study was undertaken to evaluate the susceptibility of various gram-negative organisms to several antimicrobial compounds. In addition to determining the incidence of infection with various organisms, we attempted to correlate thc colony count with the presence of microscopic bactcriuria and the number of leukocytes in the urine. A total of 81 gram negative organisms were cultured from 110 urinary specimens. Fifty-nine of these had a colony count of over 50,000fml and hence were considered significant infections. E. coli was the organism most commonly cultured. Microscopic bacteruria correlated well with urinary infection but the presence of pyuria did not. Sensitivity tests demonstrated that some drugs have a predictable in vitro effect on certain organisms. Stanley Winokur N. Rachmaninoff, M.D.