Wayne State University School of Medicine - Yearbook (Detroit, MI)

Page 147 text:

ANNA ALBERT KELLER MEMORIAL AWARD FOR EXCELLENCE IN MEDICAL RESEARCH 1967 John Skirgaudas WILLIAM BEAUMONT SOCIETY ORIGINAL RESEARCH AWARD 1967 jan I-I. Nyboer john D. Fisher Larry Bernstein

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In Conzendation of ye Miero.w,'oj1e Of all th'lnuentions none there is Surpasses the Noble Florentineslgj Dioptrich-glasses. For what a better, fitter, guift Could hee in this world's Aged Luciocity To I-lelpe our Blindnesse so as to deuize a paire of new df Artifieiall eyes, By whose augmenting power wee now see more then all the world Has euer donn Before. lj Galilei Dr. HENRY PQWER 1061

Page 148 text:

IMMUNOGENIC CHA RACTERISTICS OF BOVINE PANCREATIC RIBONUCLEASE AS DETERMINED BY PASSIVE CUT ANEOUS ANAPHYLAXIS When the immune reaction occurs in the skin h . , t ere results an increase in the permeability of the capillaries. This reaction can be visualized if a dye is injected intra- venously along with thc antigen several hours after the intradermal injection of antibody. Passive cutaneous anaphylaxis CP.C.A.l was utilized t study the immunologic properties of the enzyme ribonu clease. It was shown that the extent of P.C.A. varies directl with the quantity of antibody injected intradermally. Another finding was that certain divalent polypeptide frag ments of the intact antigen were sufficient to elicit P.C.A while particular univalent polypeptides could inhibit th combination of the antigen with its antibody. This inhibi tion was effective only if the polypeptide was injecte immediately prior to challenge with the antigen. This in hibition could be prolonged if the polypeptide was ester ifiedg thereby forming a compound of linking covalentl with the antigen-combining sites on the antibody molecule Lawrence F. Gaynor Ray K. Brown, M.D., Ph.D.