University at Buffalo School of Medicine - Yearbook (Buffalo, NY)

Page 120 text:

fDr. william jiarveg

Page 119 text:

-ff ,F- I p ' ' l 'L vi I . Quik I a A ' 1 l I A- I ' 'll' in . I .---- G , . u . Carl Gerard's research proiecl was car- rled oul in +he Biophysics deparimenl' under lhe lulelage of Dr. Sidney Shulman. His sludy was confined lo lhe purificalion of human plasminogen, a proenzyme o'F ihe fibrinolyfic or clol-lysing prolein plasmin. The densil -gradienl' ulfracenlrifugafion of moderaleaf pure malerial was +he ap- proach used. This procedure requires a densily gradienl' of carefully layered su- crose solulions of decreasing concenlra- lions upon which lhe prolein sample is layered. The preparafion is subsequenlly ceniriluged for several hours al high speed lapproximalely l50,000 'limes gravilyl lo Separale l'he sample proleins according +o Their molecular weighls and sedimenfa- hon ra'l'es. The preparalion is 'lhen frac- 'lionaied +o sample +he prolein al' various Cleplhs in fhe gradienl. The samples are analyzed 'For profein concenlraiion and as- Sayed 'For polenlial proleolylic acl'ivi'Iy. Those samples showing marked improve- menl' were examined in lhe ullracenlriluge 'lor 'lheir physical homogeneily. STUDIES IN THE IDENTITY OF THE AN- TIGEN IN THE THYROID CELLS REAC- TIVE WITH AUTOANTIBODIES IN HU- MAN SERA FROM THYROIDITIS PA- TIENTS - Joseph Gerbasi The sera of palienls wilh chronic 'l'hy- roidilis have been shown lo conlain anli- bodies which reacl' wilh componenis of normal human 'lhyroid glands. These an'li- bodies can be shown +o reacl wilh lhe col- loid and 'follicular epilhelium by immuno- fluorescenl' slaining. One of lhe anligens presenl in lhe colloid has been shown lo be fhyroglobulin. Wilh lhe use of lhe immuno- fluorescenl' 'lechnique and specific enzy- ma'I'ic digeslions, sludies were made l'o idenfily lhe anligenlsl presenl' in lhe fol- licular epilhelium. gs? THE BEHAVIORAL AND EEG CHANGES INDUCED IN RATS BY THE INTRA- VENTRICULAR ADMINISTRATION OF URACIL METABOLITES AND ANA- LOGUES - Marla Pefer Heilbrun. Following fhe adminislralion of 6-azaur- acil, an anli-neoplaslic ageni, lo cancer palienfs, neurological sympioms and EEG changes became apparenl. In order lo siudy +he mechanism of neuroloxicify, 6- azauracil and ofher uracil analogues were adminislered +o rafs by in'ec+ion inlo lhe lhird venfricle. Slrilring behavioral and EEG changes occurred characlerized by de- pressed behavior and large amplifude slow waves on ihe EEG. The relalion of 'lhese changes impaired RNA and roiein syn- lhesis in neuronal and glial iiinclion was considered as a possible mechanism of drug aclion. if i N The clerlrships offered by lhe American Cancer Sociely, lhrough Harold Solomon, D.D.S., af Roswell Parl: Memorial Hospilal, made if possible 'For lhree denlal sludenls 'lo observe cancer and allied diseases. One sludeni' is assigned lo Memorial Hospi+al in New Yorlc Cily and fwo are assigned 'lo Roswell Parlr in. Buffalo. These clerlcships allow lhe sludenl lo observe a wide variely of cancerous oral lesions and lo allow lhe sludenl 'lo see cancer in all of ils sfages so l'ha+ he will be properly equipped lo malce an early diagnosis in his praclice and help combal' lhis dread disease by one of 'I'he besf melhods lmown loday, early delecfion. Richard Overgaard. Ross Wyman, and Howard Roclcolif gall Denl. '62l were awarded lhese 'fellowships during 'lhe summer of '6I. Mr. Roclco cenlered his sludies on 'lhe Plummer-Vinson Syndrome, while Messrs. Overgaard and Wyman sludied ameloblaslomas of lhe head and neck regions. The Plummer-Vinson Syndrome is lhoughl' especially signiiicanl as a pre-dis osing cause of oral and pharyngeal malignancy. Mr. RoclcoFl's findings were published in H7 +he December 'bl Issue of The Denial Sfudenis' Magazine.

Page 121 text:

Qrgauizatiou His proved by +l1e s+ruc1'ure of +l1e l1ear+ +ha+ +he blood is perpe+ually fransferred +hrough fhe lungs in+o 'rhe aor+a, as by +wo clacks of a wafer bel- lows +o raise wa+er. His proved by fhe ligaiure 'rl1a+ +l'1ere'is a fransii' of blood from +l1e arferies +o flue veins: where- by i+ is demons+ra+ed +l1a+i'l1e perpe+- ual movemenl' of+l1e blood in a circle is brougl'1+ aboui by 'rhe bear of 'rhe l1ear+. ls +l1is 'for +he sake of nu'rri+ion, or +l1e beH'er preserva+ion of fhe blood and membiers by infusion of heal, +l'1e blood in +urn being cooled by hearing +l1e members and healed by +l1e l1ear+? William Harvey Lumleian Lecfures lblb 311