Chicago School of Medicine and Surgery - Medicos Yearbook (Chicago, IL)

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l i , i E 1 3 l l . 1 . . 1 i i -r-as-an-.-,.,-Y., I ,aa LITERATURE confirmation of this latter observation in our work in the original statement of Nlaragliano, that the serums of pathologic cases are hemolytic for the corpuscles of diseased individuals as well as for the corpuscles of normals. In regard to the nature of the isolytic substance. Ascoli was able to show that its activity was destroyed by heat, but that it could be reactivated by the addition of a fresh serum. This would seem to indicate that it was an amboceptor that depended on the presence of complement for exerting its hemolytic influence on blood corpuscles, and that it was not due to the action of any toxin produced by an infectious agent. . A On the other hand, holding in mind the experiments of von Dungern, Ehrlich and Morgenroth, Ascoli, etc., it would seem that this hemolytic property of pathologic serums was associated in some way with cell destruction, and that, as Ascoli suggests, a reaction of the organism against the absorbed products of cell destruction results in the formation of antibodies which are hemolytic. YVe examined several weeks ago, among others, a student's blood which was taken as normal. At that time his serum, which agglutinated the corpuscles of Groups 2 and 3, did not show any hemolytic action on human corpuscles. VVe examined his blood a few days ago and found that his serum hemolyzed corpuscles which it agglutinated to about the same extent as had a cancer serum in the same series of examinations. On inquiring into the history of the student during the interim of examinations, we found that he had lost about seventeen pounds in weight. I-Ie denied any infection and said that he felt well, but tired. I-Ie attributed his loss of weight to increase of work and loss of sleep in preparing for state examinations. The circumstances in this instance, in which a normal-acting serum was converted into a pathologic- acting serum, would seem to support the theory that the isohemolytic property of serum is dependent on absorption products orvantibodies of absorption products of abnormal cell degeneration. In reviewing the literature of this subject and in analyzing our own work, which we find to conform to the earliest observations on this subject, we can see no reason for bringing this isohemolytic action of serums into specific relation with any one disease or condition. On the other hand, we can confirm Maragliano's original observation, that the serums of many pathologic cases may exert an hemolytic infiuence on the blood corpuscles of normal and diseased individuals. Tho faided haunts beguile my soul In high esteem I hold that goal W hich leads me on from day to day To prove myself, that those may say To whom was given Just iaith s reward In truth thy words and deeds accord E I-I K Page 195 rn' EL'21'L's2 - M- -1'-Nw ' - -f-vff ' W Q x:---Q --- .wwf-:aa-1-A----W 4... ...J ,.....-A ---K --,f-J,Q.4-,.f.u..s.-w.w9:.u..zru-- tweak- 11 ug-1 my-:..a..:,rz-.ux1,m..-..4..r..' '- f....x.4 nuaaummauz. u.-v.z4..muvmm.1 -manga 3 5 i 1 B l F I f I i I P l 5 rl l ,. l l l 9 l 1 l. l l' 5 ' ll I Q l Ii I I i I l i il 1 if 1 1 i ' ' 1 l , l - -' ij a. i v . gl - j ., 1' i , ' f 1 Y i , 5 . ?l 1 ' ' I , li , if i 2 I I 1 I - 9 4 ,l , . I . I L: 1 ' , . 2 g V 5 . . ,- . , 5 . ' y ': -4 yi ll i ' 1 u ' 2 My . . . , ' l:- W 5 f Q, li , 'i , if '7 - I- i v l f f : ll H l 5 l. f , fl 5 l ,f i 1 ' . Z L I, l , K ' J n I 5 I l 5 E 2 l 1 E fl s 3 e f 1 P I T f 1 i 1 l , fi ' i 5 ' El 1 s 1 . fl , , 5 : I f ' , 52 3 . . rf 1 ' 2 4 1 I it l , V

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